Crash diets often send dieters into a cycle of quick weight loss, followed by a rebound weight gain once normal eating resumes. And that makes it even more difficult to attempt to loss weight when the next weight loss diet is attempted. But science has yet to come up with a low-risk magic pills for weight loss.
Natural weight loss works because it makes your body work more efficiently. It's the most successful method of long-term weight loss simply because you are using your body for what it was meant to be used for (movement) and you are fueling it with the best possible fuel (fresh foods). That's not to say you won't lose weight when you use weight loss pills, but if you do, you'll put it all back on as soon as you stop taking them.
All the evidence we have is that nothing works better than a healthy diet and increased physical activity, with or without weight loss drugs. Because of their faster metabolisms, it also appeared they had less chance of developing diabetes because they processed sugar more quickly. Learn proper portion sizes and eat in a balanced way to lose weight.
An important way to lower your calorie intake is to learn and practice healthy eating habits. A can-do attitude will help you get over the inevitable hurdles of weight loss. There are hundreds of diets that will help you lose weight, but what good is losing weight if you gain it right back.